Biography
C.-R. Shyu received his MSEE and PhD degrees in Electrical and Computer Engineering from Purdue University in 1994 and 1999, respectively. After one year of post-doctoral training at Purdue, he joined the Computer Science Department at the University of Missouri in October 2000. Currently he is the Director of the University of Missouri Informatics Institute (MUII) and holds the Shumaker Endowed Professorship. He is also affiliated with several institutions as an adjunct faculty of MU Sinclair School of Nursing, MU School of Information Science and Learning Technologies, and University of Utah Biomedical Informatics Department. During his tenure at Mizzou, he received several awards including six Departmental Teaching Awards, College of Engineering Junior Faculty Research Award, and the National Science Foundation (NSF) CAREER Award in 2005. He is the founding director of the Medical and Biological Digital Library Research Lab where a crew of students are working on several research projects in the areas of biomedical informatics, geospatial informatics, data mining and computer vision. Project sponsors for his researches include the National Science Foundation, the National Institute of Justice, the National Geospatial-Intelligence Agency, the National Cancer Institute, U.S. Department of Education, University of Missouri Research Board, University of Missouri-Columbia Research Council, and other organizations both for-profit and not-for-profit. C.-R. Shyu is a senior member of IEEE and members of ACM, AMIA, and AAAS.

Publications

• Pin-Hao Chi, Bin Pang, Dmitry Korkin, and Chi-Ren Shyu. Efficient SCOP fold classification and retrieval using index-based protein substructure alignments (IPSA), in Bioinformatics 2009; (to appear)
• Adrian Barb, and Chi-Ren Shyu. Visual semantic modeling in content-based geospatial information retrieval using associative mining techniques, in Geoscience and Remote Sensing Letters 2009; (to appear)
• Y. Liu, Lawrence W C. Chan, and Chi-Ren Shyu. Editorial for the special issue of knowledge discovery and management in biomedical information systems, in Information Systems Frontiers 2009
• Wu He, Sanda Erdelez, Feng-Kwei Wang, and Chi-Ren Shyu. The effects of conceptual description and search practice on users’ mental models and information seeking in a case-based reasoning retrieval system, in Information Processing and Management, Vol. 44, No. 1 , January 2008; 294-309
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Bob R. Stewart, and Jane Armer. Post-Op Swelling and Lymphoedema Following Breast Cancer Treatment, in Journal of Lymphoedema, Vol. 3, No. 2 2008; 20-25
• Laritza M. Taft, R. Scott Evans, Chi-Ren Shyu, Marlene J Eggger, Nitesh Chawla, Joyce A Mitchell, Sidney N Thornton, Bruce Bray, and Michael W Varner. Countering Imbalanced Datasets to Improve Adverse Drug Event Predictive Models in Labor and Delivery, in Journal of Biomedical Informatics, (to appear) 2008
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Bob R. Stewart, and Jane Armer. Breast Cancer Treatment, BMI, Post-Op Swelling/Lymphoedema, in Journal of Lymphoedema, Vol. 3, No. 2 2008; 38-44
• Grant Scott, and Chi-Ren Shyu. Knowledge Driven Multidimensional Indexing Structure for Biomedical Media Database Retrieval, in IEEE Transactions on Information Technology in Biomedicine, Vol. 11, No. 3 , May 2007; 320-331
• X. F. Wan, X. Wu, G. Lin, S. Holton, R. A. Desmone, Chi-Ren Shyu, Y. Guan, and M. Emch. Computational identification of reassortments in avian influenza viruses, in Avian Diseases, Vol. 51 2007; 434-439
• H. Oh, S. -Y. Yoon, and Chi-Ren Shyu. How Does Virtual Reality Reshape Furniture Retailing, in Clothing and Textile Research Journal, to appear 2007
• Chi-Ren Shyu, Matt Klaric, Grant Scott, Adrian Barb, Curt Davis, and Kannappan Palaniappan. GeoIRIS: Geospatial Information Retrieval and Indexing System - Content Mining, Semantics Modeling, and Complex Queries, in IEEE Transactions on Geoscience and Remote Sensing, Special Issue on Image Mining, Vol. 45, No. 4 , April 2007; 839-852
• Chi-Ren Shyu, Jason Green, D. P. K. Lun, Toni Kazic, M. Schaeffer, and Ed Coe. Image Analysis for Mapping Immeasurable Phenotypes in Maize, in IEEE Signal Processing Magazine, Vol. 24, No. 3 , May 2007; 116-119
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Shih-Chun Ho, and C. Alec Chang. Domain-Concept Association Rules Mining for Large Scale and Complex Cellular Manufacturing Tasks, in Journal of Manufacturing Technology Management, Vol. 18, No. 7 , November 2007
• Chi-Ren Shyu, Jaturon Harnsomburana, Jason Green, Adrian Barb, Toni Kazic, M. Schaeffer, and Ed Coe. Searching and mining visually-observed phenotypes of maize mutants, in Journal of Bioinformatics and Computational Biology, Special Issue on Making Sense of Mutations Requires Knowledge Management, Vol. 5, No. 6 , December 2007; 1193-1213
• Pin-Hao Chi, Chi-Ren Shyu, and D. Xu. A fast SCOP fold classification system using content-based E-Predict algorithm, in BMC Bioinformatics, Vol. 7:362 2006
• Pin-Hao Chi, Grant Scott, and Chi-Ren Shyu. A fast protein structure retrieval system using image-based distance matrices and multidimensional index, in International Journal of Software Engineering and Knowledge Engineering, Vol. 15, No. 3 , Special Issue on Software and Knowledge Engineering Support in Bioinformatics 2005; 527-545
• Jeffrey Reneker, and Chi-Ren Shyu. Refined repetitive sequence searches utilizing a fast hash function and cross species information retrievals, in BMC Bioinformatics, Vol. 6 2005
• Adrian Barb, Chi-Ren Shyu, and Yash Sethi. Knowledge Representation and Sharing Using Visual Semantic Modeling for Diagnostic Medical Image Databases, in IEEE Transactions on Information Technology in BioMedicine, Vol. 9, No. 4 , December 2005; 538-553
• Chi-Ren Shyu, Pin-Hao Chi, Grant Scott, and D. Xu. ProteinDBS - A content-based retrieval system for protein structure database, in Nucleic Acids Research, Vol. 32, July 2004; W572-W575
• E. D. Johnson, P. E. Pancoast, Joyce A Mitchell, and Chi-Ren Shyu. Evaluation of a PDA-based alerting service for clinicians, in Journal of the Medical Library Association, Vol. 92, No. 4 , October 2004; 438-444
• Jeffrey Reneker, Chi-Ren Shyu, Peiyu Zeng, Joe Polacco, and Walter Gassmann. ACMES: fast multiple-genome searches for short repeat sequences with concurrent cross-species information retrieval, in Nucleic Acids Research, Vol. 32 2004; W649-W653
• Alex M. Aisen, Lynn S. Broderick, H. Winer-Muram, Carla E. Brodley, Avi C. Kak, Christina Pavlopoulou, Jennifer Dy, Chi-Ren Shyu, and A. Marchiori. Automated Storage and Retrieval of Medical Images to Assist Diagnosis: Implementation and Preliminary Assessment, in Radiology 2003
• Feng-Kwei Wang, J. Moore, John Wedman, and Chi-Ren Shyu. Developing a case-based reasoning knowledge repository to support the technology integration community, in Educational Technology Research and Development., Vol. 51, No. 3 2003; 45-62
• Toni Kazic, Ed Coe, Mary Polacco, and Chi-Ren Shyu. Whither biological database research, in OMICS: A Journal of Integrative Biology, Vol. 7, No. 1 2003; 61-65
• Jaturon Harnsomburana, Chi-Ren Shyu, Yash Sethi, Rajdeep Singh, and John Reid. A hybrid query approach for radiology education -integrating content-based medical image Retrieval and Text-Based Information Retrieval, in International Journal on Computers and Applications, Vol. 24, No. 2 2002; 83-92
• Chi-Ren Shyu, Christina Pavlopoulou, Avi C. Kak, Carla E. Brodley, and Lynn S. Broderick. Using Human Perceptual Categories for Content-Based Retrieval from a Medical Image Database, in Computer Vision and Image Understanding, Vol. 88, No. 3 2002; 119-151
• Susan Wei, C-M Chen, G. Strathdee, Jaturon Harnsomburana, Chi-Ren Shyu, F. Rahmatpanah, H. Shi, S-W Ng, P. S. Yan, K. P. Nephew, R. Brown, and Tim H-M Huang. Methylation microarray analysis of late-stage ovarian cancinomas distinguishes progression-free survival in patients and identifies candidate epigenetic markers, in Clinical Cancer Research, Vol. 8, No. 7 , July 2002; 2246-2252
• Chi-Ren Shyu, Carla E. Brodley, Avi C. Kak, Akio Kosaka, Alex M. Aisen, and Lynn S. Broderick. ASSERT: A physician-in-the-loop content-based retrieval system for HRCT image databases, Computer Vision and Image Understanding, Special Issue on Content-Based Access of Image and Video Libraries, in Computer Vision and Image Understanding, Special Issue on Content-Based Access of Image and Video Libraries, Vol. 75, No. 1/2 , July/August 1999; 111-132

• Jason Green, and Chi-Ren Shyu. A Computational Approach for Scoring Visually Observed Phenotypic Expression in Maize, in The 49th Maize Genetics Conference, March 2007
• Toni Kazic, Jason Green, Jaturon Harnsomburana, and Chi-Ren Shyu. Quantification of Lesion Phenotypes as a Function of Inbred Background, in The 49th Maize Genetics Conference, March 2007
• X. Wu, S. Holton, Chi-Ren Shyu, G. Lin, and X. F. Wan. Computational Genotyping of Avian Influenza Virus, in the 6th International Symposium for Avian Influenza, Cambridge, UK, April 2006
• Wannapa Kay Mahamaneerat, and Chi-Ren Shyu. Knowledge Discovery using Domain-Concept Mining Approach for the Behavioral Risk Factor Surveillance System (BRFSS) Data, in American Medical Informatics Association (AMIA) Annual Symposium, Washington DC, November 2006
• Tetsuya Kobayashi, and Chi-Ren Shyu. Representing Clinical Questions by Semantic Type for Better Classification, in American Medical Informatics Association Annual Symposium, Washington DC, November 2006
• Chris Topinka, and Chi-Ren Shyu. Predicting Cancer Interaction Networks Using Text-Mining and Structure Understanding, in American Medical Informatics Association (AMIA) Annual Symposium, Washington DC, November 2006
• P. E. Pancoast, Arthur Smith, and Chi-Ren Shyu. Codifying Semantic Information in Medical Questions Using Lexical Sources, in MedINFO, San Francisco, CA, September 2004
• Mingshu Cao, D. A. Sleper, P. R. Arelli, C. A. Roberts, and Chi-Ren Shyu. Classifier Development from Near Infrared Spectroscopy Derived Data to Predict SCN Resistance, in ASA-CSSA-SSSA (American Society of Agronomy, Crop Science, Society of America, Soil Science Society of America) Annual Meetings, Indianapolis, IN, November 2002
• Bernard Ewigman, E. Lindbloom, Tim Patrick, M. H Hauan, Chi-Ren Shyu, and J. Hickner. The family practice inquiries network (FPIN) research mission, in Society of Teachers of Family Medicine 35th Annual Spring Conference, San Francisco, April/May 2002

• Matt Klaric, Grant Scott, and Chi-Ren Shyu. Progressive Spatial Clustering Of Content-Based Satellite Imagery Retrieval Results, in Proc. of IEEE International Geoscience and Remote Sensing Symposium 2010 2010
• Wannapa Kay Mahamaneerat, and Chi-Ren Shyu. Mining Associations from the CDC’s Behavioral Risk Factor Surveillance System Database to Assist Policy Making, in Enhancing Healthcare Education, Research & Practice Symposium, Hong Kong, China, July 2007
• Jason Green, Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Janice N. Cormier, Mugur V. Geana, Saskia J. Thiadens, and Jane Armer. Knowledge Discovery from the National Lymphedema Network Survey Data, in the 21st International Congress of Lymphology 2007, Shanghai, China, September 2007
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Tetsuya Kobayashi, Orawan Nukaew, Bob R. Stewart, and Jane Armer. An Examination of Post-Op Swelling and Occurrence of Lymphedema Following Breast Cancer Treatment, in the 21st International Congress of Lymphology 2007, Shanghai, China, September 2007
• Jane Armer, Wannapa Kay Mahamaneerat, Tetsuya Kobayashi, Orawan Nukaew, Bob R. Stewart, and Chi-Ren Shyu. Occurrence of Lymphedema Following Breast Cancer Treatment Using BMI-adjusted Volume Change, in the 21st International Congress of Lymphology 2007, Shanghai, China, September 2007
• Adrian Barb, and Chi-Ren Shyu. User-Specific Semantics for Modeling Content-Based Information in Geospatial Knowledge, in IEEE International Geoscience and Remote Sensing Symposium, Barcelona, Spain, July 2007
• Tetsuya Kobayashi, and Chi-Ren Shyu. A Computational Approach to Detect Duplicate Clinical Questions for the Family Physicians Inquiries Network, in Enhancing Healthcare Education, Research & Practice Symposium, Hong Kong, China, July 2007
• Pin-Hao Chi, and Chi-Ren Shyu. Predicting Ranked SCOP Domains by Mining Associations of Visual Contents in Distance Matrices, in Proc. of The Fourth Asia Pacific Bioinformatics Conference, Taipei, Taiwan 2006; 49-58
• Chi-Ren Shyu, Jason Green, Cynthia Farmer, Toni Kazic, Ed Coe, M. Schaeffer, C. Lawerence, M. Millard, P. Cyr, and C. Gardner. A Framework of Complex Queries For Plant Phenotype Image Databases, in The International Conference on Plant, Animal, and Microbe Genomes XIV 2006
• Chi-Ren Shyu, Jason Green, Cynthia Farmer, Toni Kazic, Ed Coe, M. Schaeffer, M. Millard, P. Cyr, and C. Gardner. A Computational Approach for Characterizing Standardized Phenotypic Images for Maize, in The 48th Maize Genetics Conference 2006
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, Shih-Chun Ho, and C. Alec Chang. A Multi-Level Domain-Concept Association Rules Mining for Large-Scaled and Complex Cellular Manufacturing Tasks, in the 4th International Conference on Supply Chain Management and Information Systems, Taichung, Taiwan, July 2006; 414-422
• Chi-Ren Shyu, Matt Klaric, Grant Scott, and Wannapa Kay Mahamaneerat. Knowledge Discovery by Mining Association Rules and Temporal-Spatial Information from Large-Scale Geospatial Image Databases, in Proc. of International Geoscience and Remote Sensing Symposium, Denver, CO, July/August 2006
• Matt Klaric, Grant Scott, Chi-Ren Shyu, Curt Davis, and Kannappan Palaniappan. A Framework for Geospatial Satellite Imagery Retrieval Systems, in Proc. of International Geoscience and Remote Sensing Symposium, Denver, CO, July/August 2006
• Matt Klaric, Grant Scott, and Chi-Ren Shyu. Mining Visual Associations from User Feedback for Weighting Multiple Indexes in Geospatial Image Retrieval, in Proc. of International Geoscience and Remote Sensing Symposium, Denver, CO, July/August 2006
• B. C. Claywell, Curt Davis, and Chi-Ren Shyu. Fusion of Spectral and Spatial Information for Automated Change Detection in High Resolution Satellite Imagery, in Proc. of International Geoscience and Remote Sensing Symposium, Denver, CO, July/August 2006
• Grant Scott, Matt Klaric, and Chi-Ren Shyu. Modeling Multi-Object Spatial Relationships for Satellite Image Database Indexing and Retrieval, in Lecture Notes in Computer Science (LNCS), Vol. 3568, Singapore, July 2005; 247-256
• Matt Klaric, Grant Scott, Chi-Ren Shyu, and Curt Davis. Automated Object Extraction through Simplification of the Differential Morphological Profile for High-Resolution Satellite Imagery, in Proc. of International Geoscience and Remote Sensing Symposium, Seoul, Korea, July 2005; 1265-1268
• Chi-Ren Shyu, Grant Scott, Matt Klaric, Curt Davis, and Kannappan Palaniappan. Automatic Object Extraction from Full Differential Morphological Profile in Urban Imagery for Efficient Object Indexing and Retrievals, in Proceedings of 3rd International Symposium Remote Sensing and Data Fusion Over Urban Areas (URBAN 2005), Tempe, Arizona, March 2005
• Chi-Ren Shyu, Adrian Barb, and Curt Davis. Mining image content associations for visual semantic modeling in geospatial information retrieval and indexing, in Proc. of International Geoscience and Remote Sensing Symposium, No. 5622 , July 2005
• Pin-Hao Chi, Grant Scott, and Chi-Ren Shyu. A fast protein structure retrieval system using image-based distance matrices and multidimensional index, in Proc. of IEEE Fourth Symposium on Bioinformatics and Bioengineering, Taichung, Taiwan 2004
• Adrian Barb, Chi-Ren Shyu, and Yash Sethi. Semantic integration and knowledge exchange for diagnostic medical image databases, in Proc. of IEEE Fourth Symposium on Bioinformatics and Bioengineering (BIBE2004), Taichung, Taiwan, May 2004; 175-182
• Grant Scott, and Chi-Ren Shyu. EBS k-d Tree: An Entropy Balanced Statistical k-d Tree for Image Databases with Ground-Truth Labels, in Proc. of the International Conference of Image and Video Retrieval 2003
• Adrian Barb, and Chi-Ren Shyu. Semantics modeling in diagnostic medical image databases using customized fuzzy membership functions, in IEEE International Conference on Fuzzy Systems, St. Louis, MO, May 2003; 1159-1164
• Jaturon Harnsomburana, and Chi-Ren Shyu. A Hybrid Tree Approach for Efficient Image Database Retrieval with Dynamic Feedback, in Proc. of International Conference on Pattern Recognition, Quebec, Canada, August 2002; 236-266
• Chi-Ren Shyu, and Jaturon Harnsomburana. A case-base retrieval system for knowledge innovation for technology in education (KITE), in Proc. of the Sixth World Multiconference on Systemics, Cybernetics, and Informatics, Vol. 2, Orlando, FL, July 2002; 228-233
• Adrian Barb, and Chi-Ren Shyu. A semantic query approach for diagnostic image database management - content-based access and knowledge exchange using XML, in Proc. of the Sixth World Multiconference on Systemics, Cybernetics, and Informatics, Vol. XVIII, Orlando, FL, July 2002; 162-167
• Wannapa Kay Mahamaneerat, Chi-Ren Shyu, P. S. Yan, and Tim H-M Huang. Applying Data Mining and Gene Selection for Cancer Research, in 7th Annual Asia Pacific Decision Sciences Institute (APDSI) Annual Meeting, Bangkok, Thailand, July 24-27 2002
• Peiyu Zeng, Joe Polacco, and Chi-Ren Shyu. Development of repetitive sequence search engine for functional genomic study, in The International Conference on Plant, Animal, and Microbe Genomes X, San Diego, CA, January 2002
• Feng-Kwei Wang, Chi-Ren Shyu, and David Jonassen. Knowledge innovation for technology in education (KITE), in International Conference on Society of Information Technology and Teacher Education (SITE 2002), Nashville, TN, March 2002
• J. Strobel, D. Cernusca, Feng-Kwei Wang, David Jonassen, John Wedman, Chi-Ren Shyu, J. Moore, Wu He, Jaturon Harnsomburana, T. Means, and H. C. Hsieh. Learning to Integrate Technology with the Classroom: A Case-Based Reasoning Approach, in Annual Meeting of ED MEDIA: World Conference on Educational Multimedia, Hypermedia, & Telecommunications, Denver, Colorado, June 2002
• Chi-Ren Shyu, and Pascal Matsakis. Spatial lesion indexing for medical image databases using force histograms, in Proc. of IEEE Int. Conf. on Computer Vision and Pattern Recognition, Vol. 2, Kauai, Hawaii, December 2001; 603-608
• Chi-Ren Shyu, Jaturon Harnsomburana, and Danuwat Phasuk. A hybrid query approach for radiology education - integrating content-based medical image retrieval and text-based information retrieval, in IASTED International Conference Internet and Multimedia Systems and Applications, Las Vegas, Nevada, November 2000; 436-441
• Chi-Ren Shyu, Tony Cai, and Lynn S. Broderick. Archiving and retrieval of sequential images from tomographic databases in PACS, in Proc. of SPIE - the International Society for Optical Engineering, Vol. 3656 1999; 33-40
• Jennifer Dy, Carla E. Brodley, Avi C. Kak, and Chi-Ren Shyu. The customized-queries approach to CBIR, in Proc. of IEEE Conference on Computer Vision and Pattern Recognition, Fort Collins, Colorado, June 1999

• Sean MacArthur, Carla E. Brodley, and Chi-Ren Shyu. Relevance feedback decision trees in content-based image retrieval, in Proc. of the IEEE Workshop on Content-Based Access of Image and Video Libraries, Hilton Head, SC, June 2000; 68-72
• Carla E. Brodley, Avi C. Kak, Jennifer Dy, Chi-Ren Shyu, and Lynn S. Broderick. Content-based retrieval from medical image databases: A synergy of human interaction, machine learning and computer vision, in Proc. of the Sixteenth National Conference on Artificial Intelligence (AAAI'99), Orlando, FL, July 1999
• Chi-Ren Shyu, Avi C. Kak, Carla E. Brodley, and Lynn S. Broderick. Testing for human perceptual categories in a physician-in-the-loop CBIR system for medical imagery, in Proc. IEEE Workshop of Content-Based Access of Image and Video Libraries, Fort Collins, Colorado, June 1999; 102-108
• Chi-Ren Shyu, Carla E. Brodley, Avi C. Kak, Akio Kosaka, Alex M. Aisen, and Lynn S. Broderick. Local versus global features for content-based image retrieval, in Proc. IEEE Workshop of Content-Based Access of Image and Video Libraries, Santa Barbara, CA, June 1998; 30-34

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